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Index > Protein center > SERPINH1(Gene name) > Human
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  • SERPINH1 (Gene name),
  • Serpin H1 (Protein name ),  SERPH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SERPINH1(PIG14;CBP1;CBP2;HSP47;SERPINH2);
    Protein name:
    Serpin H1;
    Alternative:
    Arsenic-transactivated protein 3(AsTP3);47 kDa heat shock protein;Collagen-binding protein(Colligin);Cell proliferation-inducing gene 14 protein;Rheumatoid arthritis-related antigen RA-A47;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
    Subcellular Location:
    Endoplasmic reticulum lumen
    Protein Attributes:
    Sequence length:
    418
    Sequence:
    50:
    MRSLLLLSAF | CLLEAALAAE | VKKPAAAAAP | GTAEKLSPKA | ATLAERSAGL | 
    100:
    AFSLYQAMAK | DQAVENILVS | PVVVASSLGL | VSLGGKATTA | SQAKAVLSAE | 
    150:
    QLRDEEVHAG | LGELLRSLSN | STARNVTWKL | GSRLYGPSSV | SFADDFVRSS | 
    200:
    KQHYNCEHSK | INFRDKRSAL | QSINEWAAQT | TDGKLPEVTK | DVERTDGALL | 
    250:
    VNAMFFKPHW | DEKFHHKMVD | NRGFMVTRSY | TVGVMMMHRT | GLYNYYDDEK | 
    300:
    EKLQIVEMPL | AHKLSSLIIL | MPHHVEPLER | LEKLLTKEQL | KIWMGKMQKK | 
    350:
    AVAISLPKGV | VEVTHDLQKH | LAGLGLTEAI | DKNKADLSRM | SGKKDLYLAS | 
    400:
    VFHATAFELD | TDGNPFDQDI | YGREELRSPK | LFYADHPFIF | LVRDTQSGSL | 
    418:
    LFIGRLVRPK | GDKMRDEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serpin H1
    Cat.:
    E0266h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Serpin H1
    Cat.:
    E0266m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Serpin H1
    Cat.:
    E0266c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Serpin H1
    Cat.:
    E0266b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Serpin H1
    Cat.:
    E0266r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin H1
    Cat.:
    U0266r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin H1
    Cat.:
    U0266m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin H1
    Cat.:
    U0266b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Serpin H1
    Cat.:
    U0266c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin H1
    Cat.:
    U0266h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Serpin H1
    Cat.:
    P0266Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serpin H1
    Cat.:
    P0266Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serpin H1
    Polyclonal Antibody for Human Serpin H1
    Polyclonal Antibody for Human Serpin H1
    Cat.:
    P0266Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Serpin H1
    Monoclonal Antibody for Human Serpin H1
    Monoclonal Antibody for Human Serpin H1
    Monoclonal Antibody for Human Serpin H1
    Monoclonal Antibody for Human Serpin H1
    Protein for Human Serpin H1
    Protein for Human Serpin H1
    Protein for Human Serpin H1
    Protein for Human Serpin H1
    Protein for Human Serpin H1

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    Linearity
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    References
    1. 1.
      "Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins."
      Clarke E. , Sandwal B.D.
      Biochim. Biophys. Acta1129:246-248(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fibroblast.
    2. 2.
      "Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2)."
      Ikegawa S. , Sudo K. , Okui K. , Nakamura Y.
      Cytogenet. Cell Genet.71:182-186(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47."
      Hattori T. , Takahash K. , Yutani Y. , Fujisawa T. , Nakanishi T. , Takigawa M.
      J. Bone Miner. Metab.18:328-334(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Cartilage.
      tissue: Fibroblast.
    4. 4.
      "Cloning and identification of human AsTP3 gene transactivated by arsenic trioxide in HepG2 cells."
      Wu S.-H. , Cheng J. , Zheng Y.-J. , Zhang Y.-X. , Liu Y. , Zhong Y.-W.
      Submitted (2004-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Identification of a human cell proliferation gene 14."
      Kim J.W.
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Ovary.
      tissue: Skin.
    10. 10.
      "A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans."
      Wang H. , Parry S. , Macones G. , Sammel M.D. , Kuivaniemi H. , Tromp G. , Argyropoulos G. , Halder I. , Shriver M.D. , Romero R. , Strauss J.F. III
      Proc. Natl. Acad. Sci. U.S.A.103:13463-13467(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM IN PROMOTER;INVOLVEMENT IN PPROM
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta."
      Christiansen H.E. , Schwarze U. , Pyott S.M. , AlSwaid A. , Al Balwi M. , Alrasheed S. , Pepin M.G. , Weis M.A. , Eyre D.R. , Byers P.H.
      Am. J. Hum. Genet.86:389-398(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OI10 PRO-78
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